This book explores the role calcium signaling plays in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. First, several chapters detail calcium release channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, transient receptor potential channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are described also in depth over many chapters. Ca2+ signaling can be expressed in Ca2+ sparks, waves, oscillations, and global changes in intracellular Ca2+ concentration. Calcium in subcellular compartments (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit dynamic crosstalk. Many molecules including FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can modify and induce spatial, temporal and compartmental variations of calcium signaling. In addition, calcium signaling can exhibit sex hormone- and age-dependent changes. A number of chapters are dedicated to covering these diverse formats, spatiotemporal characteristics, multifaceted network and mathematical modeling of Ca2+ signaling. Neurotransmitters, hormones, growth factors, inflammatory cytokines, and other stimuli may lead to multiple cellular responses by inducing Ca2+ signaling in airway smooth muscle cells. Increasing evidence suggests that Ca2+ pumps and canonical transient receptor potential channels are essential for airway smooth muscle remodeling. Accordingly, several chapters summarize recent advances in the studies of the key role of calcium signaling in physiological cellular responses as well as the development of asthma, chronic obstructive pulmonary disease and other respiratory disorders.
Puzzle fans have bought more than 650,000 copies of the Mensa Genius Quiz series--the only books that let readers "match wits with Mensa," comparing how well they do against members of the famous high-IQ society. Here, in a giant omnibus edition, are four best-selling titles: The Mensa Genius Quiz Books 1 & 2, The Mensa Genius Quiz-A-Day Book, and The Mensa Genius ABC Book. Here are more than 800 fun mindbenders Calcium Signaling in Airway Smooth Muscle Cells download ebook to exercise every part of your brain--word games, trivia, logic riddles, number challenges, visual puzzles--plus tips on how to improve your thinking skills. All the puzzles have been tested by members of American Mensa, Ltd., and include the percentage of Mensa testers who could solve each one, so that you can score yourself against some of the nation's fittest mental athletes. Vivid, witty and forthright, and taking its title not only from his politics but from his beloved Miles Davis, Kind of Blue is political memoir at its very best.
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Author: Yong-Xiao Wang
Number of Pages: 483 pages
Published Date: 23 Aug 2016
Publisher: Springer International Publishing AG
Publication Country: Cham, Switzerland
Language: English
ISBN: 9783319374581
Download Link: Click Here
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